The usefulness properties of phosphorus dendrimers in the field of nanomedicine as for exemple antiprions, antiinflammatory,and antitumoral properties ,ocular drug delivery or for the treatment of neurodegenerative diseases and for diagnosis (DNA chips), were illustrated in several reports1. On the other hand diverse phosphorus dendrimer complexes were found excellent catalysts in a number of reactions allowing the preparation in high yields of compounds of industrial interest and even of drugs.
Beside these applications there was and there is still another important field of research in which the use of phosphorus dendrimers brings interesting novelties : the design of new dendritic -based nanomaterials which potentially can lead to numerous applications in nanosciences.This will be illustrated during the lecture. Indeed it will be demonstrated that modification of the core, the internal branches, the branching points, the nature of the outer shell, allow to prepare a variety of new nano objects: fibers, capsules, divers types of nanotubes, fluorescent detectors, photoactive crystalline anatase produced at low temperature, reactive amphiphilic nanoreactors, , hierarchically controlled porous dendrimer-bridged titanium dioxide materials, textured nanospheres, surface modification of materials,etc.
The last part of the lecture will be focused on the siRNA therapy for treatment of lung inflammation using phosphorus cationic dendrimers as transfection agents. The performance of two of these dendrimers for drug delivery of siRNA directed against TNF-α was assessed in vitro in cell cultures and in vivo in mice model of acute lung inflammation
1 See for exemple: a) S. Mignani, M. Bryszewska, M. Zablocka, B. Klajnert Maculewicz, J. Cladera, D. Shcharbin, J.P. Majoral, Progress in Polymer Science, 64, 23-51, 2017; b) A.M. Caminade, A. Ouali, R. Laurent, C.O. Turrin, J. P. Majoral, Coord. Chem. Rev. 308, 478-497, 2016.